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Structure (Figure 2). Although the overall structural difference between WT and 2SHP was small, we used our WT structure as the reference for comparison with the mutant structures to exclude any potential structural changes induced by the three mutations and the detergent molecule (CTAB) in 2SHP.D61GIn the WT structure, Asp61 was located on the surface of the N-SH2 domain. The side chain of Asp61
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S3B). Thirteen genes were oppositely regulated by BaP and Clo (Additional file 1, Table S3C).Validation of tiling array results by qPCRFigure 5 The top scored process network "Muscle contraction" from Clo-modulated gene list. Mouse homologs of Clo-regulated genes were used for enrichment analysis in MetaCore. All genes shown in the network are down regulated (indicated with blue circles). For clar
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S from MARCO-/- and SR-AI/II-/- mice, they demonstrate marked decreased binding and phagocytosis of these particles compared to primary AMs from wild type mice (Fig. 6A and Fig. 7A and Fig. 7B). The results confirm that MARCO and SR-AI/II receptors on alveolar macrophages play critical roles in uptake of unopsonized environmental particles and bacteria. Moreover, the reduced, but still demonstrabl